AustralieFrV1, Main, Exploration, bibRecord, 00A630

Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia : 3-year results from the EBMT randomized trial

Identifieur interne : 00A630 ( Main/Exploration ); précédent : 00A629; suivant : 00A631

Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia : 3-year results from the EBMT randomized trial

Auteurs : Norbert Schmitz [Allemagne] ; Meral Beksac [Turquie] ; Andrea Bacigalupo [Italie] ; Tapani Ruutu [Finlande] ; Arnon Nagler [Israël] ; Eliane Gluckman [France] ; Nigel Russell [Royaume-Uni] ; Jane Apperley [Royaume-Uni] ; Jeff Szer [Australie] ; Kenneth Bradstock [Australie] ; Agnes Buzyn [France] ; Brigitte Schlegelberger [Allemagne] ; James Matcham [Royaume-Uni] ; Alois Gratwohl [Suisse]

Source :

Haematologica : (Roma) [ 0390-6078 ] ; 2005.

RBID : Pascal:05-0272518

Descripteurs français

Pascal (Inist)
- Filgrastim, Mobilisation, Cellule hématopoïétique, Leucémie, Cellule souche, Etude comparative, Homogreffe, Moelle osseuse, Traitement, Essai clinique, Hématologie, EBMT.
Wicri :
- topic : Cellule souche.

English descriptors

KwdEn :
- Bone marrow, Clinical trial, Comparative study, European group for blood and marrow transplantation, Filgrastim, Hematology, Hematopoietic cell, Homograft, Leukemia, Mobilization, Stem cell, Treatment.

Abstract

Background and Objectives. Allogeneic peripheral blood progenitor cells (PBPC) are now widely used as the source of hematopoietic stem cells for transplantation. However, it is still not clear which patients should receive mobilized PBPC or bone marrow cells to reconstitute hematopoiesis after myeloablative conditioning. The aim of this study is to present 3-year-follow-up data on outcome (incidence and severity of chronic graft-versus-host disease (GVHD), overall survival (OS) and leukemia-free survival (LFS) after a PBPC transplant (PBPCT) or a bone marrow transplant (BMT). Design and Methods. Data on 350 patients with leukemia were collected in a multicenter, randomized study initiated by the EBMT. The patients were randomized to receive filgrastim-mobilized PBSCT or BMT from an HLA-identical donor. Results. At a median follow-up of 3 years, significantly more patients transplanted with PBPC than with bone marrow developed chronic GVHD (73% vs 55%, p=0.003) and extensive chronic GvHD (36% vs 19%, p=0.002). The higher incidence and greater severity of chronic GvHD had little impact on the patient's performance status or survival. OS was 58% for PBPCT recipients versus 65% among those undergoing BMT. LFS was 56% for PBPCT recipients versus 60% for BMT recipients. Interpretation and Conclusions. Patients transplanted with PBPC from an HLA-identical sibling develop more chronic GvHD than those transplanted with bone marrow, but the final impact of this difference is unclear. Longer follow-up is necessary to characterize the impact of chronic GvHD on quality of life, leukemia-free survival and overall survival.

Affiliations:

Allemagne, Australie, Finlande, France, Israël, Italie, Royaume-Uni, Suisse, Turquie
Angleterre, Basse-Saxe, Grand Londres, Hambourg, Nouvelle-Galles du Sud, Île-de-France
Hambourg, Hanovre, Londres, Paris, Sydney

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 004925
to stream PascalFrancis, to step Curation: 001778
to stream PascalFrancis, to step Checkpoint: 004602
to stream Main, to step Merge: 00B252
to stream Main, to step Curation: 00A630

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia : 3-year results from the EBMT randomized trial</title>
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<author><name sortKey="Russell, Nigel" sort="Russell, Nigel" uniqKey="Russell N" first="Nigel" last="Russell">Nigel Russell</name>
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<s2>Nottingham</s2>
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<author><name sortKey="Apperley, Jane" sort="Apperley, Jane" uniqKey="Apperley J" first="Jane" last="Apperley">Jane Apperley</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Dept. of Hematology, Imperial College School of Medicine, Hammersmith Hospital</s1>
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<author><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Bone Marrow Transplant Service, The Royal Melbourne Hospital</s1>
<s2>Victoria</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bradstock, Kenneth" sort="Bradstock, Kenneth" uniqKey="Bradstock K" first="Kenneth" last="Bradstock">Kenneth Bradstock</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Hematology Department, Institute of Clinical Pathology and Medical Research, Westmead Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
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<author><name sortKey="Buzyn, Agnes" sort="Buzyn, Agnes" uniqKey="Buzyn A" first="Agnes" last="Buzyn">Agnes Buzyn</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Hematology Dept., Hôpital Necker</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schlegelberger, Brigitte" sort="Schlegelberger, Brigitte" uniqKey="Schlegelberger B" first="Brigitte" last="Schlegelberger">Brigitte Schlegelberger</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Institute for Cellular and Molecular Pathology, Hannover Medical School</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Matcham, James" sort="Matcham, James" uniqKey="Matcham J" first="James" last="Matcham">James Matcham</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Amgen Ltd</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Amgen Ltd</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Division of Hematology, Dep. Internal Medicine, Kantonsspital Basel</s1>
<s2>Basel</s2>
<s3>CHE</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
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<series><title level="j" type="main">Haematologica : (Roma)</title>
<title level="j" type="abbreviated">Haematologica : (Roma)</title>
<idno type="ISSN">0390-6078</idno>
<imprint><date when="2005">2005</date>
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<title level="j" type="abbreviated">Haematologica : (Roma)</title>
<idno type="ISSN">0390-6078</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bone marrow</term>
<term>Clinical trial</term>
<term>Comparative study</term>
<term>European group for blood and marrow transplantation</term>
<term>Filgrastim</term>
<term>Hematology</term>
<term>Hematopoietic cell</term>
<term>Homograft</term>
<term>Leukemia</term>
<term>Mobilization</term>
<term>Stem cell</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Filgrastim</term>
<term>Mobilisation</term>
<term>Cellule hématopoïétique</term>
<term>Leucémie</term>
<term>Cellule souche</term>
<term>Etude comparative</term>
<term>Homogreffe</term>
<term>Moelle osseuse</term>
<term>Traitement</term>
<term>Essai clinique</term>
<term>Hématologie</term>
<term>EBMT</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cellule souche</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Background and Objectives. Allogeneic peripheral blood progenitor cells (PBPC) are now widely used as the source of hematopoietic stem cells for transplantation. However, it is still not clear which patients should receive mobilized PBPC or bone marrow cells to reconstitute hematopoiesis after myeloablative conditioning. The aim of this study is to present 3-year-follow-up data on outcome (incidence and severity of chronic graft-versus-host disease (GVHD), overall survival (OS) and leukemia-free survival (LFS) after a PBPC transplant (PBPCT) or a bone marrow transplant (BMT). Design and Methods. Data on 350 patients with leukemia were collected in a multicenter, randomized study initiated by the EBMT. The patients were randomized to receive filgrastim-mobilized PBSCT or BMT from an HLA-identical donor. Results. At a median follow-up of 3 years, significantly more patients transplanted with PBPC than with bone marrow developed chronic GVHD (73% vs 55%, p=0.003) and extensive chronic GvHD (36% vs 19%, p=0.002). The higher incidence and greater severity of chronic GvHD had little impact on the patient's performance status or survival. OS was 58% for PBPCT recipients versus 65% among those undergoing BMT. LFS was 56% for PBPCT recipients versus 60% for BMT recipients. Interpretation and Conclusions. Patients transplanted with PBPC from an HLA-identical sibling develop more chronic GvHD than those transplanted with bone marrow, but the final impact of this difference is unclear. Longer follow-up is necessary to characterize the impact of chronic GvHD on quality of life, leukemia-free survival and overall survival.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Finlande</li>
<li>France</li>
<li>Israël</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>Turquie</li>
</country>
<region><li>Angleterre</li>
<li>Basse-Saxe</li>
<li>Grand Londres</li>
<li>Hambourg</li>
<li>Nouvelle-Galles du Sud</li>
<li>Île-de-France</li>
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<country name="France"><region name="Île-de-France"><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name>
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   |wiki=    Wicri/Asie
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   |clé=     Pascal:05-0272518
   |texte=   Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia : 3-year results from the EBMT randomized trial
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia : 3-year results from the EBMT randomized trial

Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia : 3-year results from the EBMT randomized trial

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